3/15/2023 0 Comments Illuminate edu![]() The times of the sessions varied depending on Sarah’s schedule. The sessions took place in the second author’s (M.G.’s) studio, located at the University of Nebraska at Omaha. Sarah had a total of 9 portrait sessions from October 2020 to July 2021. Sarah is an intensive care unit charge and rapid response nurse who has been working on the front lines of the Covid-19 pandemic in Nebraska since the beginning, all the while experiencing major life changes and caring for 4 small children. Two participants were based in New York 1 in Houston 1 in Washington, DC 1 in Boston and 9 in the Midwest. Sarah was recruited as part of a convenience sample of 14 health care participants, including 5 nurses, 7 clinicians, a hospital chaplain, and a psychotherapist. 4 Although portraiture is not intended as therapy, the relationship established between artist and sitter in portraiture allows the healing power of stories to be shaped and shared visually and verbally. 2 Portraiture, an emerging form of arts-based research, “bridge the realms of science and art.” 3 It seeks to study relational and aesthetic aspects of clinical interactions in medicine, such as trust, vulnerability, and reflection-qualities required for successful artist-sitter and doctor-patient interactions. 1 The nuance of art invites audiences to experience the world in ways unseen or previously inaccessible. Art’s capacity to adumbrate-or faintly indicate, foreshadow, or symbolize-is what Barone and Eisner say allows meaning to be derived from art. Science is necessary but not sufficient to address the complexity and nuance needed to navigate an ever-evolving and uncertain climate.Īrts-based research captures what science cannot, as it seeks to depict subtle yet complex interactions, ambiguities, and vulnerabilities in a perceptible way. The Covid-19 pandemic has shed a harsh light upon difficulties in health decision making. The article also includes Sarah, a charcoal study drawing for that portrait, and Front Lines of Care, a 3 by 3 collection of 9 smaller oil on canvas portraits. This article presents Shadow of Corona, a large oil on canvas portrait commissioned by the AMA Journal of Ethics to commemorate the American Medical Association’s 175th year. This article describes an arts-based research protocol exploring portraiture as a medium for representing and understanding clinicians’ experiences, mostly during the first year of the pandemic. Overall, the dual-channel responsive performance renders this probe as a powerful imaging tool to decipher Aβ plaque–ONOO – interactions, which will facilitate AD-associated molecular pathogenesis elucidation and multitarget drug discovery.Portraits of clinicians quickly became emblematic of what the COVID-19 pandemic has demanded of everyone, especially caregivers who witnessed deaths likely unprecedented in number during their careers. Furthermore, by coimaging of the level dynamics of Aβ plaques and ONOO –, we found that the cerebral ONOO – is a potential biomarker, which emerges earlier than Aβ plaques in transgenic mouse models. The two critical events, ONOO – stress and Aβ aggregation, mutually amplify each other through positive feedback mechanisms and jointly promote the AD onset and progression. Notably, Aβ aggregates induce the neuronal ONOO – generation, which conversely facilitates Aβ aggregation. ![]() With this probe, for the first time, we comonitored the distribution and variation of Aβ plaques and ONOO – through two independent fluorescence channels, demonstrating their close apposition and tight correlation during AD course in live cell and mouse models through two-photon imaging mode. Herein, a novel ONOO – reaction trigger was installed onto an Aβ plaque binding fluorophore to generate a dual functional fluorescent probe, displaying completely separate spectral responses to Aβ plaques and ONOO – with high selectivity and sensitivity. To address this concern, as proof of principle, we rationally designed a unimolecular fluorescent probe to discriminate and simultaneously profile amyloid-β (Aβ) plaques and peroxynitrite (ONOO –), which are both the pronounced AD pathological factors. However, such significant investigations remain a major challenge due to the lack of unimolecular fluorescent probes capable of simultaneous and discriminative visualization of multiple targets. Therefore, the comonitoring of different factors is particularly valuable for elucidating their level dynamics and complex interactions. Alzheimer’s disease (AD) involves multiple pathological factors that mutually cooperate and closely contact to form interaction networks for jointly promoting the AD progression.
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